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Association of fat distribution with changes in bone outcomes in young girls
Author(s) -
Laddu Deepika,
Lee Vinson R,
Blew Robert M,
Going Scott B
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.343.8
Subject(s) - quantitative computed tomography , bone mineral , medicine , bone density , femur , endocrinology , surgery , osteoporosis
Background Childhood obesity may impair bone growth but the relationship remains unclear. Objective Examine longitudinal associations between total body fat (TBF), android fat (AF), and skeletal muscle fat (SMF) content, with bone outcomes in 260 girls aged 8–13y. Methods Peripheral quantitative computed tomography measured changes in bone strength index (BSI, mg 2 /mm 4 ), strength‐strain index (SSI, mm 3 ) and volumetric bone density (vBMD, mg/cm 3 ) at distal metaphyseal and diaphyseal regions of the femur (fem) and tibia (tib), and baseline calf (CMD) and thigh (TMD) muscle density (mg/cm 3 ), an index of SMF content. Baseline TBF and AF were assessed by dual‐energy X‐ray absorptiometry. Results TBF and AF were positively associated with fem BSI (r=0.193; r=0.174), tib SSI (r=0.184; r=0.142), and fem trabecular vBMD (r=0.196; r=0.203), and inversely associated with tib cortical vBMD (r= −0.146; r= −0.172). Lower CMD and TMD was associated with fem BSI (r= −0.222; r= −0.145), tib BSI (r= −0.193; r= −0.128), fem tot vBMD (r= −0.208; r= −0.168), and trabecular vBMD (fem: r= −0.263; r= −0.192, tib: r= −0.215; r= − 0.161). CMD was significantly associated with tib SSI (r= −0.141) and tot vBMD (r= −0.130). ANCOVA showed that girls in the middle thirds of TBF and AF had higher fem and tib cortical vBMD than girls with greater TBF and AF. Greater changes in fem BSI, tot fem vBMD and fem and tib trabecular vBMD were observed in the lowest vs. highest thirds of CMD and TMD. All results were significant at p<0.05. Conclusions Gains in TBF or AF may negatively impact tib bone development, while increases in CMD or TMD predict greater gains in various bone outcomes. Grant Funding Source : NIH/NICHD #HD‐050775