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Novel enzymatic transformations in secondary metabolism and tRNA modification
Author(s) -
Bandarian Vahe
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.337.1
Subject(s) - transfer rna , nucleoside , biosynthesis , enzyme , biochemistry , secondary metabolism , biology , computational biology , chemistry , rna , gene
Deazapurine‐containing secondary metabolites comprise a broad range of structurally diverse nucleoside analogs found throughout biology including various antibiotics produced by species of Streptomyces bacteria and the hypermodified tRNA bases queuosine and archaeosine. Despite early interest in deazapurines as antibiotic, antiviral, and antineoplastic agents, the biosynthetic route toward deazapurine production had remained largely elusive for more than 40 years. We have utilized genomic and biochemical studies to identify a paradigm for the biosynthesis of deazapurine‐containing compounds. This presentation will discuss our most recent efforts towards molecular level understanding of the reactions catalyzed by enzymes in the deazapurine biosynthesis pathways. (Support from GM72623 is gratefully acknowledged)