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1 The use of an ad libitum higher‐protein, low‐glycemic index diet in overweight children: the Diogenes Study
Author(s) -
Astrup Arne,
Damsgaard Camilla T,
Papadaki Angeliki,
Jensen Signe M,
Dalskov StineMathilde,
Hlavaty Petr,
Saris Wim H.M.,
Martinez J. Alfredo,
HandjievaDarlenska Teodora,
RohrAndersen Malene,
Stender Steen,
Larsen Thomas M,
Mølgaard Christian,
Michaelsen Kim F
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.249.8
Subject(s) - overweight , waist , medicine , glycemic , obesity , blood pressure , body mass index , endocrinology , glycemic index , insulin
Effect of higher‐protein, low GI diet on body weight and cardiovascular risk factors was studied in 253 children (5–18 yrs) of overweight/obese parents. Families were randomized to 1 of 5 ad lib diets for 6 months: high protein (HP) or low protein (LP) with either high GI (HGI) or low GI (LGI); or control. In 6 centres children received dietetic instruction, in 2 centres diet adherence was ensured by free provision of all foods at study shops. Measurements conducted month 0, 1 and 6. Dietary protein content was slightly higher in HP than LP (20.7±0.7 vs 17.9±0.7E%, P=0.004), with greater difference at shop centres (25.1±1.2 and 17.0±1.1 E%, P<0.001). GI was reduced by 3.5 points in LGI vs HGI (P<0.001). HP produced 2.6 cm (P=0.007) greater reduction in waist circumference and 0.25 mmol/L (P=0.003) lower serum LDL cholesterol than LP. In the supermarket centres HP resulted in reduction in BMI z‐scores (P=0.01), waist circumference (3.5 cm, P=0.003), diastolic blood pressure (0.8 mmHg, P=0.007), MAP (0.7 mmHg, P=0.008), insulin (P=0.02), HOMA‐IR (P=0.02) and HDL cholesterol (P=0.04) vs LP. Increased protein intake improved cardiovascular markers in high‐risk children, particularly with most intensive intervention. EU FOOD‐CT‐2005–513946/ www.diogenes‐eu.org