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THE RESPONSE TO VITAMIN E SUPPLEMENTATION
Author(s) -
Guertin KA,
Agler AH,
LaBarre J,
Parker RS,
Kristal AR,
Arnold KB,
Hartline J,
Goodman PJ,
Tangen CM,
Minasian LM,
Lippman SM,
Klein E,
Cassano PA
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.242.1
Subject(s) - vitamin e , vitamin , medicine , plasma concentration , antioxidant , endocrinology , physiology , biology , biochemistry
Background Vitamin E has antioxidant properties, which may promote some health outcomes. Plasma vitamin E levels vary widely, and more so among supplement users, however little is known about individual characteristics that affect the degree to which plasma concentrations increase with supplementation. Methods We investigated the association between participant characteristics and change in plasma concentration in response to vitamin E supplementation (400 mg/day all rac α‐tocopheryl acetate) over three years in participants of the Respiratory Ancillary Study (RAS) to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Results African American men had lower baseline plasma α‐tocopherol concentration, and had a 50% lower increase in concentration in response to supplementation in comparison to others (p<0.0001), independent of cholesterol and other covariates. Conclusions Future studies should consider the magnitude of the change in plasma concentration in relation to the effects of supplementation. The lower response in African Americans may indicate less possible benefit, or may indicate metabolic consumption of the supplemented nutrient, thus more benefit. Grant Funding Source : NIH RO1HL071022, NCI/DCPCA37429, NCCAM