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Long‐term feeding of dietary slow release glucose reduces daily caloric food intake in vivo
Author(s) -
Yan Like,
Philllips Robert,
Powley Terry,
Kinzig Kim,
Kim Choon Young,
Hamaker Bruce
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.237.6
Subject(s) - meal , chemistry , starch , food science , food intake , orexigenic , endocrinology , medicine , biology , biochemistry , receptor , neuropeptide y receptor , neuropeptide
A true dietary slowly digestible starch is not yet available, thus its long‐term effect on food intake has yet to be elucidated. Aim Examine the long‐term effect of a dietary slowly digestible starch material on food intake in vivo . Methods Alginate‐entrapped starch microspheres with different slow digesting rates were incorporated into rodent diets. Diet‐induced obese Sprague Dawley rats were assigned to 5 test groups and fed for 8 wks: 1) 14% low‐fat diet; 2) 45% high‐fat (HF) diet; 3) 45% HF with rapidly digestible starch; 4) 45% HF with slowly digestible microspheres; and 5) 45% HF with more slowly digestible microspheres. Meal patterns were monitored using BioDAQ. Results A slowly digestible microsphere group had lower daily food intake compared with the 45% HF rapidly digestible starch group (P < 0.05) and similar food intake as the low fat group. Overall meal size was lower in slow digesting microspheres group and meal frequency decreased over time (P < 0.05). mRNA levels of orexigenic NPY and AgRP lowered in microspheres group to a similar level as low‐fat group. Conclusion Chronic dietary slow release glucose reduces daily caloric food intake by changing meal size and meal frequency.