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Blueberry and blackcurrant consumption increases bone mineral density and content in high fat diet‐induced obese male mice
Author(s) -
Lee Sang Gil,
Vance Terrence,
Soung Do Yu,
Kim Bohkyung,
Lee Jiyoung,
Koo Sung I.,
Drissi M. Hicham,
Chun Ock K.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.233.8
Subject(s) - bone mineral , endocrinology , medicine , obesity , bone mineral content , antioxidant , epiphysis , chemistry , food science , anatomy , osteoporosis , biochemistry
We have recently reported that berry polyphenols exert strong antioxidant and anti‐inflammatory effects, which might substantially contribute to the improvement of bone health specifically under obese conditions. Thus, this study was aimed to evaluate the impact of three different berry supplements (blueberry: BB, blackberry: BK, and blackcurrant: BC) on the improvement of bone health using diet‐induced obese C57BL/6J mice. Forty of 12 wk old male mice were assigned into 4 groups and fed 60% high fat diet with/without freeze‐dried berry powders (BB: 5%, BK: 6.3%, and BC: 5.7%) for 12 wks. Plasma insulin‐like growth factor 1 (IGF‐1) levels were measured by ELISA. Bone mineral density (BMD) and bone mineral content (BMC) of femoral proximal and distal epiphysis were measured using DXA. We found that the body weight and IGF‐1 levels were comparable among all experimental groups. However, the BB‐treated group exhibited higher BMD in the proximal and distal epiphysis as well as increased BMC in the distal epiphysis compared to untreated controls (P<0.05). Furthermore, BC‐treated group showed higher BMC in the proximal and distal epiphysis compared to the control (P<0.05). Our findings imply that BB and BC may be effective natural supplements for enhancing bone formation. Further investigations are warranted to delineate the mechanisms underlying these osteogenic effects of BB and BC in vivo.