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Longitudinal changes in bone turnover markers following Roux‐en‐Y gastric bypass surgery
Author(s) -
Rogers Tara Sheree,
Havel P J,
Wolfe B M,
Blankenship J,
Stanhope K L,
Van Loan M D,
Swarbrick M M
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.233.4
Subject(s) - bone remodeling , gastric bypass surgery , medicine , gastric bypass , alkaline phosphatase , endocrinology , n terminal telopeptide , roux en y anastomosis , hormone , weight loss , obesity , chemistry , osteocalcin , biochemistry , enzyme
Bariatric surgery is associated with changes in bone metabolism; the mechanism is unclear. We examined changes in bone turnover for 1 yr following Roux‐en‐Y gastric bypass surgery (RYGBP). Obese adults (n=20; BMI 45.6 ±1.6 kg/m 2 ) were studied pre and 1, 3, 6, and 12 months post‐RYGBP. Bone specific alkaline phosphatase (BAP) and N‐telopeptide of type I collagen (NTx) were measured by ELISA. ANOVA was used to evaluate differences over time. We modeled the contributions of body weight, energy related hormones and inflammatory markers to BAP and NTx. The BAP/NTX ratio declined significantly (p<0.0001) within 1 month of surgery and remained low for 12 mo. post RYGB. Before surgery, glucose and free fatty acids (FFA) explained 35.3% of the variance in BAP/NTX; post RYGBP, 48% of variance in BAP/NTx was explained by glucose, insulin and c‐reactive protein (CRP). Neither weight nor composition contributed to the BAP/NTX ratio. BAP and NTx may be influenced by energy related hormones and inflammatory markers; more research is needed to elucidate relationships among these variables and bone metabolism.Pre Partial R 2 12‐Mo Post Partial R 2Intercept −0.32656 4.07734Glucose 0.01826 0.2334 −0.040 0.216 FFA 1.96974 0.1198Insulin0.00848 0.169 CRP−0.05015 0.101 Model R 20.353 0.481Funding: UC Davis Health Care Systems grant; UC Davis CTSC (UL1 RR024146); National Center for Research Resources; USDA/ARS/WHNRC.