Premium
The associations between serum antioxidant concentrations and bone mineral density in women aged 50 and over: an analysis of NHANES 2005–6
Author(s) -
Hamidi Maryam Sarah,
Cheung Angela ManWei
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.233.3
Subject(s) - medicine , bone mineral , confounding , femoral neck , national health and nutrition examination survey , endocrinology , vitamin , physiology , vitamin e , vitamin d and neurology , beta carotene , antioxidant , osteoporosis , population , chemistry , environmental health , biochemistry
It has been shown that diets high in antioxidants are associated with high bone mineral density in postmenopausal women. Conversely, some studies suggest that dietary supplements containing antioxidants may have detrimental effects on bone. Serum concentrations of antioxidants can reflect their intakes from both food and supplements. Thus, the objective of our study was to examine the associations between serum concentrations of several antioxidants and femoral neck BMD (FN_BMD) in postmenopausal women aged ≥50 years. We used cross‐sectional data from the NHANES 2005–6. Multiple regression models with adjustments for relevant confounders were used to examine the associations between serum concentrations of vitamins C and E (alpha‐ and gamma‐tocopherol) and alpha and beta‐carotene, and FN_BMD. The study sample included 168 women, with a mean age of 67.5±0.5 years, who were free from diseases and medications that affect bone metabolism, and were fasting >;9 hours prior to examination. In adjusted models, serum concentration of vitamin C had a positive association with FN_BMD (p=0.018), while serum concentration of beta‐carotene had a negative association with FN_BMD (p=0.008). The association between higher serum vitamin C and higher BMD in our study is consistent with findings of other studies. The negative association between serum beta‐carotene and femoral neck BMD needs further investigation. Grant Funding Source : None