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Decaffeinated green tea extract and voluntary exercise alters the expression of genes related to lipid metabolism and mitochondrial biogenesis in liver and skeletal muscle in high fat‐fed mice
Author(s) -
Saetan Sudathip,
Rogers Connie J,
Lambert Joshua D
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.224.6
Subject(s) - mitochondrial biogenesis , endocrinology , skeletal muscle , medicine , lipid metabolism , carnitine , peroxisome , biology , beta oxidation , chemistry , mitochondrion , biochemistry , metabolism , receptor
Obesity is a significant health problem. Studies have reported the beneficial effects of green tea for weight loss and exercise for weight management. We have previously reported the combination of decaffeinated green tea extract (GTE) and voluntary exercise (Ex) has greater effects on high fat diet‐induced obesity and comorbidities in male C57BL/6J mice than either treatment alone. Here, we report that the combination alters gene expression in the liver and skeletal muscle. mRNA levels of sterol regulatory element‐binding protein‐1c and sterol‐coenzyme A desaturase‐1, genes related to fatty acid synthesis, were increased by 1.4‐ and decreased by 0.5‐fold, respectively, by GTE+Ex treatment in the liver. Hepatic mRNA expression of peroxisome proliferatoractivated receptor‐α and carnitine palmitoyltransferase‐1α, genes related to fatty acid oxidation, were increased by 2.2‐ and 1.3‐ fold, respectively, by GTE+Ex treatment. GTE+Ex treatment also increased the mRNA expression of proliferator‐activated receptor‐ γ coactivator −1α, cytochrome b, cytochrome C oxidase subunit III by 1.5‐, 1.5‐, and 1.3‐fold, respectively, in the skeletal muscle. Our results suggest that the combination of GTE and Ex modulates the expression of several genes related to lipid metabolism and mitochondrial function. These changes may underlie the obesity preventive effects of this combination. Grant Funding Source : NIH Grant (AT004678)