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Plasma and liver lipids of iron‐deficient rats with excessive dietary manganese
Author(s) -
Yokoi Katsuhiko,
Konomi Aki,
Tachibana Itsuki,
Uchida Yuka
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.223.4
Subject(s) - medicine , concomitant , endocrinology , manganese , cholesterol , chemistry , biology , organic chemistry
Recently, manganese (Mn) toxicity in a child with iron (Fe) deficiency was reported. Since there is a possibility that effect of Fe deficiency is augmented by excessive Mn, plasma and liver lipids in rats were analyzed. Thirty‐two 3‐week‐old male Wistar rats were randomly assigned in a 2×2 factorial design (eight rats each): FeA/MnA group fed AIN‐93G diet, FeA/MnE group fed a high Mn diet (1000 ppm), FeD/MnA group fed a low‐Fe diet (no supplemental Fe), and FeD/MnE group fed a low Fe/high Mn diet. Rats were fed ad libitum for six weeks and then fasted overnight. Plasma and liver lipids were measured enzymatically. Data were analyzed by two‐way ANOVA and P values less than 0.05 was considered significant. The low Fe diet increased plasma triglycerides, phospholipids and free fatty acids. The low Fe diet decreased plasma glucose and HDL cholesterol, and concomitant high Mn augmented their reduction. The low Fe diet increased liver triglycerides. Both the low Fe and high Mn diets increased liver phospholipids. The low Fe diet increased liver cholesterol, and concomitant high Mn attenuated its rise. These results suggest that concomitant high dietary Mn modulates changes in plasma and liver lipids induced by Fe deficiency. Partly supported by Japan Society for the Promotion of Science Grants‐in‐Aid for Scientific Research (C) (22500772).