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Placental expression of the heme scavenger receptor, LDL receptor‐related protein 1, is associated with expression of placental heme exporter, feline leukemia virus C receptor 1
Author(s) -
Cao Chang,
Cooper Elizabeth,
Pressman Eva,
Guillet Ronnie,
O'Brien Kimberly O
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.223.2
Subject(s) - hemopexin , heme , placenta , lrp1 , transferrin receptor , scavenger receptor , medicine , receptor , ldl receptor , endocrinology , biology , chemistry , transferrin , lipoprotein , pregnancy , biochemistry , fetus , cholesterol , enzyme , genetics
LDL receptor‐related protein 1 (LRP 1) is the surface receptor for the plasma heme‐hemopexin complex and is involved in heme clearance following intravascular red cell destruction. Both LRP1 and the heme exporter feline leukemia virus C receptor 1 (FLVCR1) are highly expressed in the human placenta and may play a role in partitioning heme iron between the maternal and fetal compartments. To explore this possibility, protein expression of LRP1 (n=122) and FLVCR1 (n=62) were assessed in pregnant adolescents (13–18 y) in relation to plasma concentrations of the heme scavenger, hemopexin, and iron status indicators (hemoglobin, serum ferritin, transferrin receptor, and hepcidin) at mid‐gestation (~26 wks) and in maternal/cord blood at delivery. Placental LRP1 expression was positively associated with placental FLVCR1 ( r =0.41, n=62, p <0.01), maternal serum transferrin receptor at delivery ( r =0.20, n=117, p =0.03), and cord hepcidin ( r =0.22, n=113, p =0.02). Greater decreases in hemopexin across pregnancy were associated with higher placental LRP1 ( r =0.33, n=55, p =0.01). Placental LRP1 is associated with placental FLVCR1 and a maternal index of intravascular hemolysis. Further studies are needed to elucidate functional roles of LRP1 in placental iron transport. Supported by: USDA 2008–0857Grant Funding Source : USDA