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Clock 3111 T/C SNP Interacts with Saturated Fatty Acid Intake to Modulate Plasma LDL‐C Concentrations in the Boston‐Puerto Rican Health Study
Author(s) -
Dashti Hassan S,
Tucker Katherine L.,
Smith Caren E.,
Ma Yiyi,
Lee YuChi,
Ordovás José M.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.222.5
Subject(s) - single nucleotide polymorphism , dyslipidemia , snp , minor allele frequency , endocrinology , medicine , melatonin , metabolic syndrome , circadian rhythm , biology , genotype , genetics , gene , diabetes mellitus
Disruption of circadian rhythms is associated with metabolic syndrome (MetS) traits and dyslipidemia and could be induced by variants of circadian genes and a high‐fat diet. While the Clock 3111 T/C single nucleotide polymorphism (SNP) has been reported to interact with saturated fatty acid (SFA) intake to modulate MetS traits, no study has reported the interaction of this SNP with fat intake on dyslipidemia outcomes, such as elevated LDL‐C concentrations. The aim of the current study was to examine whether the association between Clock 3111 T/C SNP and plasma LDL‐C concentrations is modulated by SFA intake. Participants in the Boston‐Puerto Rican Health Study (n=772) were examined for interaction using multivariate linear regression models, where a dominant genetic model was applied. While LDL‐C did not differ between TT participants and carriers of the minor C allele (TC and CC), by dichotomizing SFA intake, we identified a significant gene‐diet interaction associated with plasma LDL‐C concentrations at this locus (P = 0.01). In the high SFA intake group (≥ 21g/d), the minor C allele was protective against elevated plasma LDL‐C concentrations (P = 0.02). This gene‐diet interaction provides additional evidence for the role of a high‐fat diet in regulating chronobiological functions and, if replicated in additional populations, may be of application for future personalized nutritional recommendations. Grant Funding Source : U.S. Department of Agriculture