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Disrupting Bacterial Communication to Suppress Multidrug Resistant Phenotypes
Author(s) -
Melander Christian
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.213.1
Subject(s) - bacteria , response regulator , regulator , histidine kinase , two component regulatory system , microbiology and biotechnology , transcription (linguistics) , kinase , phosphorylation , transcription factor , biology , efflux , chemistry , gene , genetics , bacterial protein , linguistics , philosophy , mutant
Bacteria have evolved an intricate communication network to sense and react to environmental stressors, including protection from antibiotic threats. A key bacterial sensing system is a two component system that typically involves a membrane‐bound histidine kinase (HK) sensor and cytoplasmic protein called a response regulator (RR). Upon sensing the environmental input, the HK will phosphorylate the RR and induce changes in gene transcription to help the bacteria adapt and survive to a diverse array of environmental conditions. Small molecules based upon the 2‐aminoimidazole (2‐AI) scaffold have been developed that potentiate this system and we have demonstrated that these small molecules will effectively restore susceptibility of mutldrug resistant bacteria to the action of antibiotics they are resistant to.