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The ESCRT Pathway in HIV Budding and Cytokinesis
Author(s) -
Sundquist Wesley I.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.212.3
Subject(s) - escrt , cytokinesis , budding , endosome , microbiology and biotechnology , tsg101 , abscission , biology , chemistry , cell division , cell , microvesicles , genetics , intracellular , microrna , gene
The Endosomal Sorting Complexes Required for Transport (ESCRT) pathway mediates intraluminal endosomal vesicle formation, budding of HIV‐1 and other enveloped viruses, and the final abscission step of cytokinesis in mammals and archaea. I will review our current understanding of the roles of different ESCRT factors in HIV budding and abscission. In particular, I will describe our experiments aimed at understanding how the filament‐forming ESCRT‐III subunits and the VPS4 ATPase assemble and function in membrane fission.