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Neuronal migration in the adult vertebrate brain
Author(s) -
Lois Carlos
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.18.2
Subject(s) - neurogenesis , vertebrate , neuroscience , biology , neuronal migration , neuronal circuits , neuron , biological neural network , mammalian brain , process (computing) , extracellular , anatomy , microbiology and biotechnology , computer science , gene , genetics , operating system
Most vertebrate species add new neurons to existing brain circuits throughout life, a process thought to be essential for tissue maintenance, repair, and learning. How these new neurons migrate through the mature brain and which cues trigger their integration within a functioning circuit is not known. We are studying the process of neuronal migration during adult neurogenesis using a combination of genetic labeling and in vivo imaging by 2‐photon microscopy. We observed that in adult songbirds most young newly‐generated neurons exhibit a multipolar morphology, extend dynamic processes that explore extracellular space, and migrate in a wandering manner. After 蝤2 weeks, cells stop migration in close proximity to resident neurons and begin to integrate into the circuit. These data reveal a novel form of neuron migration involved in the addition of new neurons to the postnatal brain that is not directed by pre‐established routes.