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A novel mechanism of chondrocyte column formation in growth plate cartilage
Author(s) -
Dudley Andrew T
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.14.5
Subject(s) - chondrocyte , convergent extension , cartilage , extracellular matrix , microbiology and biotechnology , morphogenesis , polarity (international relations) , matrix (chemical analysis) , chemistry , cell polarity , mechanism (biology) , anatomy , cell , biology , embryogenesis , biochemistry , embryo , physics , gastrulation , chromatography , quantum mechanics , gene
Proper morphogenesis of the long bones depends in part on the specific arrangement of chondrocytes in the growth plate cartilage. Within this tissue, actions of secreted signaling molecules regulate spatial and temporal aspects of chondrocyte maturation. One crucial step is the transition from elliptical cells that are arbitrarily arranged in the extracellular matrix to columns of discoid cells that are stacked like coins. Previously, we presented evidence that columnar organization results from convergent extension cell movements that are regulated by the planar cell polarity pathway. Using new assays, we refine this model and show a link between the signaling pathways that regulate chondrocyte maturation and the control of tissue architecture.