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Fabrication of Three‐Dimensional Cellulose Macroporous Film for Biomedical Application
Author(s) -
Shin Eun Joo,
Choi Soon Mo,
Oh Tae Hwan,
Han Sung Soo
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1217.37
Subject(s) - cellulose , leaching (pedology) , chemical engineering , dissolution , ionic liquid , porosity , fabrication , polymer , materials science , solvent , tissue engineering , chemistry , composite material , organic chemistry , biomedical engineering , medicine , environmental science , alternative medicine , pathology , soil science , engineering , soil water , catalysis
Cellulose is the most abundant naturally occurring polymer on earth produced by plants and bacteria that has been utilized in applications from paper and textiles to materials in wound healing. It has been employed in the form of membranes and bioadhesive cellulose gels as vascosurgical devices for investigations in bone tissue engineering and cartilage tissue engineering. In this work, we have focused on fabrication of cellulose scaffolds by NaCl leaching technique for bone tissue engineering. Ionic liqid(ILs) are considered as desirable green solvents because of their excellent dissolution ability, low vapor pressure, and easy of recycling. In methods based on the leaching of soluble particulates, the porosity can be effectively controlled by variation of the amount of leachable particles and the pore size of the porous structure can be adjusted independently by using particles of different sizes. The morphology and physical properties of cellulose scaffolds were investigated and in vitro experiment also carried out. The results were as follow: Porous film was perfectly contained interconnected porous network between 350~500μm in size. Cell viability of cellulose film was evaluated using a MTT assay for checking biocompatible substrate. Ionic liquid(1‐ally‐3‐methylimidazolium chloride: AmimCl) was found to be a powerful, nonderivatizing single‐component solvent for cellulose.