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Ventral respiratory column neuron interactions and discharge patterns during expression of low‐frequency or very low‐frequency brainstem network oscillations
Author(s) -
O'Connor Russell E,
Nuding Sarah C,
Segers Lauren S,
Ott Mackenzie M,
Lindsey Bruce G,
Morris Kendall F
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1214.3
Subject(s) - rostral ventrolateral medulla , brainstem , neuroscience , baroreceptor , ventilation (architecture) , rhythm , bursting , chemistry , physics , medicine , heart rate , biology , central nervous system , blood pressure , medulla oblongata , thermodynamics
Mayer and Lundberg (B) waves are oscillations of arterial pressure occurring spontaneously at a frequency lower than breathing (~0.1 Hz and ~0.04 Hz respectively). Each has been attributed to a central oscillator or an effect of baroreceptor‐mediated dynamic arterial pressure control (Julien 2006, Lescot et al. 2004). Previously we have shown that Mayer wave related oscillations (MWROs) intrinsic to the pontine and raphé networks are coupled with breathing (Morris et al. 2010). We used multi‐electrode arrays to record from neurons in the ventral respiratory column (VRC) and rostral ventro‐lateral medulla (RVLM) in decerebrate, adult cats. Results include (i) detection of neurons active only during discrete segments of MWROs, (ii) evidence for impulse synchrony of RVLM and VRC neurons with multiple coupled rhythms, and (iii) long lasting rhythm changes with central chemoreceptor stimulation. Time series analyses of spike trains informed the development of network models. Computer simulations predicted pulmonary stretch receptor‐mediated modulation of MWROs and replicated in vivo results: (i) resetting of MWRO:breathing coupling with no‐inflation cycles; (ii) change in coupling ratio with “vagotomy”. Coupling of multiple time‐scale cardio‐respiratory rhythms may assist in the matching of ventilation and perfusion and underpin the beneficial effects of slow, deep breathing. Support: NS19814