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Female sex steroid effects on basal muscle protein synthesis rates in postmenopausal women
Author(s) -
Smith Gordon I,
Reeds Dominic N,
Burrows Rachel E,
Kampelman Janine A,
Mittendorfer Bettina
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1208.6
Subject(s) - basal (medicine) , medicine , endocrinology , estrogen , menopause , postmenopausal women , hormone , androstenedione , steroid , chemistry , androgen , insulin
We recently reported a greater basal, postabsorptive rate of muscle protein synthesis (MPS) in post‐compared with premenopausal women. This finding suggests that ovarian hormones suppress MPS. In the current study, we tested this hypothesis by measuring the basal rate of MPS (by using stable isotope‐labeled tracer methods) in postmenopausal women before and after treatment with either estradiol (Mylan Pharmaceuticals; 0.1 mg/d delivered transdermally; n=6) or progesterone (Endometrin®; 100 mg/d delivered vaginally; n =5). The MPS rate was unaffected by estrogen treatment (0.063±0.006 vs. 0.063±0.010 %/h, before and after treatment respectively; P=0.99) but was markedly increased after progesterone treatment (0.102±0.018 %/h vs. 0.055±0.007; P=0.02). We conclude that the menopause associated decline in ovarian female sex hormone production is not responsible for the age‐associated increase in MPS in old women. Supported by grants from the NIH.