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The Association between Pulse Pressure and Stroke Volume during Lower Body Negative Pressure and Graded Hemorrhage
Author(s) -
Helmond Noud,
Johnson Blair D.,
Curry Timothy B.,
Convertino Victor A.,
Joyner Michael J.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1206.4
Subject(s) - pulse pressure , medicine , stroke volume , blood pressure , pulse (music) , lower body , cardiology , anesthesia , heart rate , detector , electrical engineering , engineering
Due to the relationship between stroke volume (SV) and pulse pressure (PP) during lower body negative pressure (LBNP), we hypothesized that PP reflects SV during hemorrhage (HEM). After a 5‐minute baseline, 6 men were exposed to LBNP at ‐15, ‐30, and ‐45 mmHg for 5 minutes at each pressure. After 45 minutes of recovery, three progressive 333‐ml stages of HEM (1 L total) were performed. SV was assessed using a CC Nexfin and PP was calculated using an arterial catheter. SV (111 ± 2.1 vs. 77 ± 6.7 mL; p = 0.04) and PP (58±2.7 vs. 41 ± 4.3 mm Hg; p = 0.03) decreased from baseline to ‐45 mmHg LBNP. SV (118 ± 4.4 to 99 ± 6.8 mL; p = 0.06) and PP decreased (58 ± 2.9 to 48 ± 4.9 mmHg; p = 0.06) from baseline to ‐1 L of HEM. PP correlated with SV during HEM (amalgamated r 2 = 0.98) and LBNP (amalgamated r 2 = 0.99). There was limited inter‐subject variability in PP vs. SV during LBNP ( r 2 range 0.57 to 0.99, 5/6 had an r 2 >; 0.90), but substantial inter‐subject variability during HEM ( r 2 range 0.21 to 0.99, 2/6 had an r 2 >; 0.90). Reductions in PP induced by LBNP or HEM are strongly correlated with SV. However large inter‐individual differences in this correlation during HEM, which may indicate a significantly variable compensatory response in human arterial distensibility, may limit the use of PP as a surrogate for SV during clinical blood loss. Funded by U.S. Army MRMC Combat Casualty Care Research Program Grant # W81XWH‐11–1‐0823.