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Investigation of Bisphenol A administration on skeletal muscle force generation in mice
Author(s) -
Benson Marisa C,
Liang Chen,
Receno Candace N,
DeRuisseau Keith C
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1202.20
Subject(s) - endocrinology , medicine , chemistry , estrogen , soleus muscle , skeletal muscle , bisphenol a , endocrine system , zoology , hormone , biology , organic chemistry , epoxy
Bisphenol A (BPA) is a chemical used in the manufacturing of numerous products including plastics and food‐contact materials and is classified as an endocrine disruptor because it can mimic actions of estrogen in the body. The purpose of this study was to examine BPA effects on muscle force generation since estrogen may influence muscle contractile properties. Eight‐week old male CD‐1 mice were housed in polypropylene cages and provided a soybean oil‐free diet (AIN‐93G) (control; C) for two weeks. Thereafter, animals were randomly assigned to C (n=5), C+BPA (BPA; 50 mg BPA/kg diet; n=4), or C+ethinyl estradiol (EE; 0.1 ppb; n=5) diets for one month. Soleus muscles were harvested for measurement of twitch and tetanic force generation (N/cm 2 ) in vitro. Peak twitch tension of EE (3.5±0.1) was greater (p<0.05) than BPA (2.6±0.1) and C (2.8±0.2). Peak tetanic tension of EE (24.8±1.2) was greater (p<0.05) than BPA (19.2±0.7) but was similar (p>;0.05) to C (22.31±0.3). Soleus force generation between BPA and C was similar (p>;0.05). Post‐experiment animal body mass and soleus muscle mass did not differ between groups (p>;0.05). Preliminary findings revealed augmented force generation of the soleus following administration of EE, but not BPA. Therefore, BPA administration does not appear to influence twitch or maximal force generation of mouse soleus muscle. Supported by the Hill Collaboration on Environmental Medicine (KCD)