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Short‐term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis
Author(s) -
Layec Gwenael,
Haseler Luke J,
Hoff Jan,
Hart Corey R,
Liu Xin,
Jeong EunKee
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1202.1
Subject(s) - phosphocreatine , oxidative phosphorylation , respiration , respiration rate , chemistry , oxidative metabolism , heart rate , medicine , zoology , endocrinology , energy metabolism , metabolism , biochemistry , biology , anatomy , blood pressure
Background There has not been a study that has directly assessed temporal changes in mitochondrial oxidative capacity and metabolic control as a consequence of short‐term exercise training in vivo . Methods We used 31 P‐magnetic resonance spectroscopy ( 31 P‐MRS) to examine the effect of short‐term plantar flexion exercise training on phosphocreatine (PCr) recovery kinetics and the control of respiration rate. To this aim, we investigated 12 healthy men experienced with this exercise modality (TRA) and 8 time‐control subjects (TC). Results After 5 days of training, maximum work rate during incremental plantar flexion exercise was significantly improved ( P < 0.01). During the recovery period, the maximal rate of oxidative ATP synthesis (PRE: 28 ± 13 mM.min −1 ; POST: 26 ± 15 mM.min −1 ) and the PCr recovery time constant (PRE: 31 ± 19 s; POST: 29 ± 16) were not significantly altered. In contrast, the Hill coefficient ( n H ) describing the cooperativity between respiration rate and ADP was significantly increased in TRA (PRE: n H =2.7 ± 1.4; POST: n H =3.4 ± 1.9, P < 0.05). Meanwhile, we did not observe any systematic variation in any of these variables in the TC. Conclusion This study reveals that 5 days of training induces rapid adaptation in the allosteric control of respiration rate by ADP before any substantial improvement in muscle oxidative capacity.