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Contributions of endothelial nitric oxide synthase, norepinephrine, and neuropeptide Y to local warming‐induced cutaneous vasodilation in humans
Author(s) -
Carter Stephen Jordan,
Hodges Gary James
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1201.10
Subject(s) - vasodilation , microdialysis , neuropeptide y receptor , endocrinology , medicine , nitric oxide , enos , norepinephrine , propranolol , chemistry , nitric oxide synthase , perfusion , neuropeptide , pharmacology , central nervous system , receptor , dopamine
Despite being somewhat counter‐intuitive, our previous studies have assigned a role for sympathetic neurotransmitters during vasodilation in the cutaneous vessels in response to increased local skin temperature. We examined whether norepinephrine (NE), neuropeptide Y (NPY), and endothelial nitric oxide synthase (eNOS) were involved in maintaining the cutaneous vasodilator response to increased local skin temperature. Participant forearms were fitted with microdialysis fibers, local skin heaters, and laser‐Doppler probes. Skin sites were heated to 42 °C and allowed to stabilize before drug infusion was initiated. Site 1 was perfused with yohimbine, propranolol, and BIBP3226 antagonising NE and NPY, while site 2 was perfused with L‐NAA inhibiting eNOS. The combination of sympathetic antagonists did not affect skin blood flow ( P >; 0.05), yet L‐NAA perfusion resulted in a pronounced reduction ( P < 0.05). These data indicate that sympathetic neurotransmitters do not play a role in the persistent vasodilator response to local skin warming.