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Life's simple 7 (LSS) and its associations with coronary artery calcium (CAC): the Jackson Heart Study (JHS)
Author(s) -
Talegawkar Sameera A,
Chen Ping,
Liu Jiankang,
Hickson DeMarc A,
Maras Janice,
Manjourides Justin,
Correa Adolfo,
Griswold Michael,
Taylor Herman A,
Tucker Katherine L
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.120.6
Subject(s) - medicine , agatston score , cohort , odds ratio , population , coronary artery disease , stroke (engine) , demography , odds , cohort study , cardiology , coronary artery calcium , logistic regression , mechanical engineering , environmental health , sociology , engineering
The American Heart Association (AHA) defined a LSS metric, of ideal cardiovascular (CV) health factors and health behaviors as a measure consistent with healthy longevity. Associations of this metric with CAC are not well described in African Americans (AA). An ideal CV health score was created with baseline cohort data from the JHS, a population‐based cohort of AA adults, as the sum of the 7 metrics, each coded as dichotomous variables (1 point AHA ideal, 0 for other). The total score range is 0–7, categorized as 0–1, 2–4, and 5–7. CAC was assessed at approx. 4 y after baseline with CT scans; CAC was defined as Agatston score >;0. Included in these analyses were 2,148 participants (66.5% women, mean age 54.7 y) with complete data on the CV health score, CAC, and without a history of coronary heart disease or stroke at baseline. The percentage of participants with 0, 1, 2, 3, 4, 5, 6, and 7 ideal CV health scores were 3.4, 15.3, 32.1, 29.1, 14.5, 5.2, 0.5 and 0 respectively. At 4 y follow‐up, 44% of the cohort had an Agatston score >;0. After adjustment for age, sex, and education, higher scores were associated with decreased odds of CAC. Corresponding Odds Ratios were 1.0 (score 0–1, reference), 0.41 (score 2–4, 95% CI 0.31, 0.52) and 0.30 (score 5–7, 95% CI 0.18, 0.51). In this cohort of AA adults, CV health assessed using the LSS metric was independently associated with CAC, suggesting that this is a valid measure of risk in this population.