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Leptin induces adiponectin expression: Implications in obesity
Author(s) -
Singh Prachi,
Sahakyan Karine R,
SertKuniyoshi Fatima H,
RomeroCorral Abel,
Delacroix Sinny,
Davison Diane E,
Jensen Michael D,
Somers Virend K
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1192.7
Subject(s) - adiponectin , leptin , medicine , adipokine , endocrinology , adipose tissue , obesity , white adipose tissue , insulin resistance , biology
Background Expression of adiponectin, an anti‐atherogenic and insulin‐sensitizing adipokine, is decreased in obesity. Mechanisms underlying this reduction are not well understood. Increased adiponectin in obesity may protect against development of cardiac and metabolic disorders. Objective To investigate the role of leptin in regulating adiponectin expression in humans. Design 1) determining the relationship between leptin and adiponectin in healthy humans during modest weight gain; 2) in‐vitro validation of the role of leptin in adiponectin expression. Results Modest weight gain of 3.8 ± 1.2 kg over 8 weeks of overfeeding in normal weight healthy subjects (n=33, 22 men, 30±7 years) increased both leptin and adiponectin. Changes in leptin during weight gain correlated with changes in adiponectin (rho=0.35, p=0.045), suggesting that leptin may regulate adiponectin expression. In cultured differentiated human white preadipocytes, leptin increased adiponectin mRNA and protein expression. Conclusions Leptin induces adiponectin expression. In obesity, adipose tissue may be resistant to leptin signaling thus preventing increases in adiponectin. Therefore, impaired leptin signaling may contribute to low adiponectin in obesity. Targeting leptin resistance may be beneficial in preventing obesity‐associated cardiac and metabolic disorders. Support : AHA 11SDG7260046, R21 DK81014