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Canonical correlation analysis identifies key diet macronutrients related with metabolic and cardiovascular disorders in rodents submitted to hypercaloric diet
Author(s) -
Junior Silvio Assis Oliveira,
Padovani CR,
Silva NR,
Martinez PF,
Campos DHS,
Okoshi MP,
Okoshi K,
Cicogna AC
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1192.12
Subject(s) - glycemic , medicine , endocrinology , cardiac hypertrophy , blood pressure , insulin , muscle hypertrophy
This study analyzed the correlation between diet macronutrients and cardiovascular parameters in rats subjected to hypercaloric diet (HD). Methods Wistar‐Kyoto rats (n=20) were fed a standard control (C; 3.2Kcal/g) or hypercaloric diet (HD; 4.6Kcal/g) for 20 weeks. Afterward, glycemia and insulin were evaluated in serum samples. Systolic blood pressure (SBP) was analyzed by tail pletismography. Echocardiography was used to analyze structure and performance of the heart. Morphometric analysis was assessed in myocardial histological sections. Myocardial myosin heavy chain (MyHC) isoforms were analyzed by electrophoresis. Statistical analysis Student's t‐test and canonical correlation. Results HD reduced glycemic tolerance and induced cardiac hypertrophy combined with improved systolic performance; additionally, HD increased collagen interstitial fraction (C: 3.7±1.2; HD: 5.4±1.8%; p<0.05) and β/α‐MyHC ratio (C: 0.87±0.27; HD: 1.43±0.67; p<0.05). Saturated lipid intake significantly correlated with glycemia, and multiple myocardial parameters of structure and performance (r=0.99; p<0.05). Conclusion Saturated lipids intake is directly correlated with glycemic changes and cardiac remodeling in rodents submitted to HD.