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Relationship Between Dyslipidemia and Hypertension (HBP) in Male ZDSD, a New Rat Model of Metabolic Syndrome (MetS)
Author(s) -
Eaton David M,
Rogers Ashley N,
Rice Ami E,
Coy Kathy,
Peterson Richard G,
Packer C Subah
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1190.1
Subject(s) - dyslipidemia , hypertriglyceridemia , medicine , endocrinology , triglyceride , metabolic syndrome , diabetes mellitus , cholesterol , blood pressure , obesity
MetS is epidemic and a leading cause of cardiovascular disease. The current study addressed the hypothesis that HBP develops as a consequence of dyslipidemia in a new leptin‐intact rat model, ZDSD. Cholesterol, triglyceride (TG) and BP were recorded weekly in ZDSD and CD obese controls from 6–23 weeks. Hypercholesterolemia and hypertriglyceridemia preceded HBP while diabetes was delayed. Scatter plots and linear regression were used to identify potential correlations. Student's t‐test and ANOVA followed by Neuman‐Keul's were used to determine differences between mean values for two groups or multiple groups, respectively. CD cholesterol levels were lower than in ZDSD throughout the study. However, rate of increase with aging was ~2× greater in CD than ZDSD. ZDSD had higher TGs than CD throughout the 17 weeks. While TG levels declined in both groups as cholesterol levels rose with aging, TG rate of change was 1.3× greater for ZDSD. ZDSD BP was higher than CD BP at all life stages. ZDSD became hypertensive by 9 weeks and BP rate of change was 1.9× greater for ZDSD. Interestingly, both TG levels and BP peak at about the same time in ZDSD when rats are 12–16 weeks with rise in BP slightly lagging rise in TGs. A surprising finding is the concomitant resistance of obese CD to develop hypercholesterolemia and hypertension. (D Eaton was a NSF LSAMP Scholar)