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Effect of chronic stress on cardiovascular function in adolescent and adult.
Author(s) -
Duarte Josiane O.,
Cruz Fabio C.,
Leão Rodrigo M.,
Planeta Cleopatra S.,
Crestani Carlos C.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1187.9
Subject(s) - medicine , stressor , blood pressure , adult male , young adult , diastole , heart rate , physiology , endocrinology , clinical psychology
The aim of this study was to compare the effects of two distinct protocols ‐ repeated restrain stress (RRS) and variable stress (VS) over the mean arterial pressure (MAP), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate (HR) in adult and adolescent rats. Furthermore, we investigated whether the effects observed in adolescent rats could persist to adulthood. In this way, 54 male Wistar rats (21 or 60 days old) were divided into 9 groups: 3 control groups (adolescent, adult, adult stressed in adolescence), 3 VS groups ( adolescent, adult and adult stressed in adolescence) and 3 RRS groups ( adolescent, adult and adult stressed in adolescence). The animals were submitted during 10 days to stress, once a day, the RRS persisted during 60 minutes and VS consisted in different stressors conditions. The cardiovascular functions were measured at the 11° day. Our results showed that adolescent animals presented high HR values (P<0.05), when compared to the adult animals. The adolescent animals submitted to VS protocol showed increased MAP, SAP, DAP and HR (P<0.05). All the effects observed in adolescent animals were reverted at the adulthood (P>;0.05). VS and RS increased the MAP, SAP and DAP (P<0.05) in adult rats, but just the VS increased the HR (P<0.05). In this way, our results suggest that chronic variable stress protocols seems to be more dangerous to the cardiovascular function in adult and adolescent. Furthermore, was observed that stress during adolescence were reverted during the adulthood. FAPESP 2012/01888–2.