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Central cardiovascular function during a cold challenge in raynaud's patients
Author(s) -
Ball Guy,
Hussain Zahra,
Davis John E
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1184.5
Subject(s) - medicine , cardiology , occlusion , heart rate , ischemia , blood pressure , anesthesia
The purpose of this study was to examine the relationship between the ischemia seen during a Raynaud's attack and the central cardiovascular response. It was hypothesized that during cold conditions (12° C ice bath for the hand) Raynaud's patients would demonstrate lower cardiac output (CO), coinciding with ischemia in the hand. Ten female subjects (20.2±1.0 years), five with Raynaud's (RAY) and five control (CON), completed two trials: a baseline visit and a cold‐induced visit where the hand was placed in a cold container at 12° C. Cardiac output, mean arterial pressure (MAP) and heart rate (HR) were measured at rest, during occlusion (at 250 mmHG), and after occlusion. CO was measured using a CO2 re‐breathing technique (Collier). CO, HR, and MAP were measured at each of the three times. As expected, resting CO, HR, and MAP were not different between groups (CO 3.9 ±.11 L/min, HR 73.0±9.6 bpm, and MAP 87.4±1.4 mmHG for CON; CO 3.8±.38 L/min, HR 75.6±12.3 bpm, and MAP 87.1±2.3 mmHg for RAY). Contrary to the original hypothesis however, RAY demonstrated a higher CO during the cold test than CON (4.3± .20 L/min vs. 3.6± .10 L/min, P<0.05). This disparity was greatest during post‐occlusion readings (CON 3.4 ± 1.0 vs. RAY 4.5± .9 L/min). These findings suggest a response by Raynaud's patients in which increasing cardiac output and blood flow will ultimately provide a correction for the regulatory error in the ischemic hand.