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The impact of maternal in utero environment on salt‐induced hypertension in the SS rat
Author(s) -
Geurts Aron M,
Skelton Meredith,
Kurth Terry,
Klotz Jason,
Grzybowski Michael,
Mattson David,
Liang Mingyu,
Cowley Allen W.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1182.7
Subject(s) - offspring , medicine , in utero , endocrinology , blood pressure , casein , excretion , pregnancy , embryo , biology , embryo transfer , fetus , chemistry , biochemistry , genetics , microbiology and biotechnology
The SS rat is an established model of salt‐sensitive human hypertension. We previously demonstrated that SS animals from parents fed a grain‐based diet are less susceptible to salt‐induced elevations in blood pressure and associated renal damage than SS animals fed a casein‐based protein diet. Others have shown that transfer of SS strain embryos into genetically unrelated recipients can also attenuate salt‐induced blood pressure changes. We hypothesized, therefore, that differences in dietary‐induced susceptibility may be driven by the in utero environment of pregnant females fed these different diets. Using the closely related SS/JrHsdMcwi strain (SS/Mcw), maintained on a purified casein diet, and the SS/JrHsdMcwiCrl (SS/Crl) which is maintained on a grain diet, we addressed this hypothesis by performing embryo transfers between strains and phenotyping the offspring. Compared to control male rats (n=6) generated by the transfer of SS/Mcw embryos into SS/Mcw females, males (n=9) generated by transfer of SS/Mcw embryos into SS/Crl female recipients demonstrated both significantly reduced mean arterial pressure (154 ±7 mmHg vs. 134±6) and lower urinary albumin excretion (200±19 mg/day vs. 74±14 mg/day) following three weeks of a 4.0% NaCl diet. These data demonstrated that the dietary exposure of pregnant SS female rats can impact the susceptibility of their offspring to salt‐induced hypertension.