Premium
Changes in the activity of the Renin Angiotensin System on resistance arteries in isolated perfused heart of hypertensive rats.
Author(s) -
Calderon Emilio Lopez,
Villavicencio Nallely Acevedo,
LaraPadilla Eleazar,
GuevaraBalcazar Gustavo,
Chong Enrique Hong,
CastilloHernandez Maria Carmen
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1182.5
Subject(s) - medicine , blood pressure , vascular resistance , renin–angiotensin system , cardiology , angiotensin ii , coronary arteries , renovascular hypertension , oxygenation , artery
High blood pressure (HBP) is a disease with high morbidity and mortality worldwide and is considered one of the main etiological factors of multiple cardiac pathologies. One of the regulatory mechanisms of blood pressure is the Renin Angiotensin System (RAS). It is important consider adjuvant therapies to improve the outlook and quality of life of patients with HBP. One therapy that has been shown clinically to improve the condition of patients with HBP is hyperbaric oxygenation (HBO), that consists in subjecting a subject at a pressure greater than 2 atmospheres absolute with 100% oxygen. This therapy has been shown to improve vascular smooth muscle relaxation, increasing oxygenation of hypoxic tissues, decrease the degree of fibrosis, among other beneficial effects. Methodology We used rats Wystar of 340 ± 20 g. A corresponding groups were induced hypertension of renal origin by a surgical method (cellophane method) at the eighth day after surgery we began the therapy OHB. At the end of treatment, the rats were sacrificed getting heart, this was mounted on a system of isolated organ (Langendorff system). Curves to Angiotensin II (Ang II) were obtain in coronary resistance arteries. Results The diastolic pressure measurement was obtained (150 ± 15 mmHg). The HBP group without treatment (control) showed an increase in vascular reactivity in comparison with the healthy group (control) after a dose of 1×10 −7 M of Ang II (p <0.001). Whereas the study group no presented changes in vascular reactivity to any dose of Ang II, compared to healthy control group (p>; 0.05).