Premium
α 1A adrenergic receptor influences on progenitor cell fate in the adult hippocampus
Author(s) -
Collette Katie,
Nielsen Amber,
Perez Dianne,
Doze Van
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1177.11
Subject(s) - subgranular zone , dentate gyrus , neuroscience , neurogenesis , neural stem cell , hippocampus , progenitor cell , biology , genetically modified mouse , stem cell , receptor , microbiology and biotechnology , transgene , subventricular zone , genetics , gene
Long‐term stimulation of α 1A adrenergic receptors (α 1A ARs) increases the number of proliferating cells in the subgranular zone (SGZ) of the adult dentate gyrus and enhances learning and memory in the mouse. The creation of new neurons in the SGZ of the adult brain has been linked with improved learning and memory in mouse, rat, and primate models. The role of the new neurons in learning and memory has not been fully examined though some studies show that the new cells play different roles as immature and mature cells. We used transgenic mouse models to determine the effect of chronic α 1A AR activation on differentiation and survival of the adult‐generated cells in the hippocampus. Animals were injected with BrdU to label dividing cells and perfused 4 weeks later to allow time for the new cells to differentiate. Immunohistochemical markers were used to identify the new cells which included excitatory granule cells, astrocytes, and a very small number of the interneurons. Supported by North Dakota EPSCoR IIP Seed Award Grant EPS‐081442, National Center for Research Resources Grant P20RR016741 and National Institute of General Medical Sciences Grant P20GM103442 from the NIH, NHLBI Grant RO1HL61438, NSF Graduate Research Fellowship Program, and NSF MRI Grant 0619688.