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Effect of Enalapril and Losartan on Testosterone induced Benign Prostatic Hyperplasia in rats
Author(s) -
PATEL SANDIP BHIKHUBHAI,
PATEL VRUSHANT,
CAPTAN HEMANT
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1170.4
Subject(s) - finasteride , losartan , hyperplasia , testosterone (patch) , prostate , medicine , enalapril , endocrinology , urology , benign prostatic hyperplasia (bph) , renin–angiotensin system , angiotensin converting enzyme , blood pressure , cancer
The aim of the present investigation is to establish the therapeutic potential of drugs affecting Renin Angiotensin System (RAS) on Testosterone induced Benign prostatic hyperplasia (BPH) in rats. Animals were distributed in 5 groups (6 rats each). Group 1 receives only vehicles. Four other groups injected with Testosterone (3mg/kg) to produce BPH, Group 2 was model group, Group 3 animals were treated with Enalapril at a dose of 10mg/kg, Group 4 animals were treated with Losartan at a dose of 10mg/kg, Group 5 animals were treated with Finasteride at a dose of 5mg/kg. The drugs were administered once a day for 21 days consecutively. On 22 nd day, blood samples were collected from the Retroorbital plexus, centrifuged to obtain serum for determination of various parameters. Then animals were sacrificed, prostates, Testis were weighed and histopathological studies of prostate were carried out. Enalapril and Losartan treatment showed significant inhibition of prostate enlargement, prevent the reduction in Serum Testosterone levels, reduced the level of Serum Prostate Specific Antigen, reduced the level of Serum Prostatic Acid Phosphatase, protection of histoarchitecture of prostate when compared with model group. These results suggest that ACE inhibitor and Angiotensin‐II antagonist has a definite inhibitory effect on BPH and might be an alternative medicine for treatment of human BPH.