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The Antidiabetic Activities of the Aqueous Leaf Extract of Phyllanthus amarus In Some Laboratory Animals
Author(s) -
Adedapo Adeolu Alex,
Ofuegbe Sunday Oluwaseun
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1167.9
Subject(s) - glibenclamide , phyllanthus , traditional medicine , aqueous extract , diabetes mellitus , alloxan , medicine , pharmacology , endocrinology
The Antidiabetic Activities of the Aqueous Leaf Extract of Phyllanthus amarus In Some Laboratory Animals Aims Phyllanthus amarus has gained popularity in many continents as an herbal remedy hence its aqueous leaf extract is being assessed for its safety potential and antidiabetic properties in some laboratory animals. Methods The anti‐diabetic activities of the aqueous extract of the plant were assessed using some standard tests as well as histological changes in liver, kidney and pancreas. Diabetes mellitus was induced in rats using alloxan while glibenclamide at 0.2mg/kg was the reference drug used in this study. Acute toxicity was carried out to determine safe doses for this plant extract. Results The extract at 200 and 400mg/kg body weight caused significant reduction of fasting blood glucose, produce significant reduction in the oral glucose tolerance test, marked effect in the hypoglycaemic activity test, and pronounced reduction on the glucose level of diabetic rats. Histopathologically, the architecture of the pancreas appeared intact in the extract‐treated group. The study also showed recovery of the damaged liver cells in the extract‐ treated group. Conclusion The plant extract produced antidiabetic activities that are comparable to that of Glibenclamide, and may have validated the basis for the traditional use of Phyllanthus amarus as antidiabetic agent.