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Angiotensin II receptor signaling modulates vascular smooth muscle sensitivity to nitric oxide in an adiposity‐specific manner in healthy adults
Author(s) -
Christou Demetra D.,
Hwang MoonHyon,
Walker Ashley E.,
Zigler Melanie,
Seals Douglas R.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1165.22
Subject(s) - medicine , candesartan , brachial artery , endocrinology , placebo , angiotensin ii , nitric oxide , cardiology , overweight , vascular smooth muscle , body mass index , blood pressure , smooth muscle , pathology , alternative medicine
Vascular function (VF) is a predictor of cardiovascular disease (CVD) risk. Angiotensin II (Ang II) contributes to impaired VF in patients with CVD, but its influence on healthy adults is unknown. We tested the hypothesis that Ang II modulates VF in adults free of CVD and that this influence is related to adiposity. Acute Ang II receptor blockade (ARB; 16 mg candesartan) was administered in a randomized, double‐blind, placebo‐controlled, cross‐over study in 27 healthy men varying in adiposity (body mass index; 18 to 38 kg/m 2 ). We measured total body fat (dual energy x‐ray absorptiometry) and abdominal fat (computed tomography) at baseline and vascular endothelial function (brachial artery flow‐mediated dilation; FMD) and vascular smooth muscle sensitivity to nitric oxide (NO) (brachial artery dilation to 0.4 mg sublingual nitroglycerin; NID) after ARB and placebo. In the overall group, ARB had no effect on FMD (6.2±0.5 vs. 5.8±0.6%, P=0.4; ARB vs. placebo) and NID (16.5±0.8 vs. 16.8±0.9%, P=0.6). Among individuals, the change in NID with ARB was inversely related to total and abdominal body fat measures (r=−0.43 to −0.49, P=0.01 to 0.04). In subgroups, ARB increased NID in normal/overweight men (< 30 kg/m 2 ), whereas, ARB decreased NID in obese (≥ 30 kg/m 2 ) men (1.80±0.61 vs. −2.18±0.87%, P=0.001). In conclusion, Ang II modulates vascular smooth muscle sensitivity to NO in healthy men in an adiposity‐specific manner.