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Effects of the Momordica charantia (MC) in the alterations caused by administration of a high fat diet (HL) as a model of non‐alcoholic fatty liver disease (NAFLD)
Author(s) -
Santos Maria Emilia Soares Martins,
Lemos Bruno Silva Oliveira,
Teixeira Keyt Braz,
Silva Lilian Nayra,
Souza Geovana Alves,
Pinto Flávia Carmo Horta,
Santos Lima Luciana Alves Ribeiro,
Santos Maria Emilia Soares Martins
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1154.19
Subject(s) - medicine , very low density lipoprotein , endocrinology , fatty liver , cholesterol , chemistry , high density lipoprotein , alanine transaminase , triglyceride , lipoprotein , disease
The aim of this work was to study the effects of MC on metabolism from NAFLD animals. Mice received a control (C) or a HL diet/8 weeks. One HL group was administered with MC extract/5days (HLT5) after the diet period. Other HL group received MC tea (HLTT) instead of water at the same period of diet. Blood was collected for analysis of glucose (GLU), cholesterol (CTO), high density lipoprotein (HDL), triacylglycerol (TAG), alanine aminotransferase (ALT) and very low density lipoprotein (VLDL). Liver was removed for histology. HL showed an increase in body weight (35.0 ±0.8 vs 48.3 ±1.0), liver weight (C 1.7 ±0.07 vs HL 2.6 ±0.01), GLU (562.1±13.4 vs 701.8 ±20.1), ALT (57.3 ±6.4 vs 105.1 ±6.1), CTO (145.8 ±9.9 vs 195.2±14.9), HDL (107.7± 0.6 vs 171.9 ±8.7), VLDL (21.5 ±1.54 vs 34.8 ± 6.8) and TAG (75.0 ±6.6 vs 171.5±34.4) in comparison to C. MC extract administration decreased: GLU (701.8 ±20.1 vs 306.7 ±31.0), CTO (195.2 ±14.9 vs 103.6 ±4.6), VLDL (34.8 ± 6.8 vs 8.6 ± 0.5), HDL (171.9 ±8.7 vs 97.1 ±7.8), TAG (171.5 ±34.4 vs 43.4 ± 2.6), liver weight (2.6 ±0,01 vs 1.7 ±0.13). HLTT animals decreased: GLI (661.8±26.2 vs. 528.5±57.9), VLDL (37.5±4.142 vs. 9.7±1.1) and TAG (174.07±16.71 vs. 48.9±5.64) in comparison to HL. Significant improvement was observed histologically in liver from animals with NAFLD when they received MC. MC seems to be efficient in treatment/preventing hyperglycemia, hyperlipidemia and NAFLD. Financial support: CNPq