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Severe left ventricular dysfunction following short‐term high fat feeding in a canine model
Author(s) -
Nelson Michael,
Broussard Josiane,
Kolka Cathryn,
Bediako Isaac Asare,
Szczepaniak Lidia S.,
Bergman Richard
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1153.10
Subject(s) - ejection fraction , medicine , cardiology , stroke volume , diastole , basal (medicine) , endocrinology , cardiac function curve , cardiac magnetic resonance imaging , heart failure , ventricular remodeling , impaired glucose tolerance , magnetic resonance imaging , obesity , blood pressure , insulin resistance , insulin , radiology
This study tested the effects of short‐term high fat feeding on left ventricular function. Experiments were conducted in 4 mongrel dogs at baseline (normal chow: 40/30/30 carb/fat/protein), and after 2 and 6 weeks of high fat feeding (30/50/20 carb/fat/protein). Each condition included an intravenous glucose tolerance test for metabolic assessment, along with cardiac magnetic resonance imaging (cMRI) to evaluate left ventricular (LV) volumes, mass, and myocardial deformation (by tissue tagging). Remarkably, 2‐wk of high fat feeding dramatically worsened (all p<0.05) LV ejection fraction (mean+SD;−11.8+6.6%), circumferential strain (CS,+4.6+1.7%), circumferential strain rate (CSR,+34.7+16.0%/s) and LV torsion (−4.3+2.0°), with no changes in LV mass, heart rate, or glucose tolerance. By week 6, LV end‐diastolic volume significantly increased above baseline (+9.3+7.7 mL), returning ejection fraction closer to its basal level (−3.2+1.9%), while CS, CSR, and torsion remained impaired. Mechanisms responsible for impaired cardiac function from a short period of fat feeding with a modest increase in body weight need to be further elucidated. Support: Heart and Stroke Foundation of Canada (MN), Branco Weiss Fellowship (JB), NIH DK27619, DK 29867.