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The combined effects of Anastrozole and Testosterone or Trenbolone on Prostate and Levator Ani‐Bulbo Cavernosus Mass
Author(s) -
Beck Darren Thomas,
Yarrow Joshua F,
McCoy Sean C,
Beggs Luke A,
Ye Fan,
Balaez Alexander,
Combs Sarah M,
Miller Julie R,
Conover Christine F,
Borst Stephen E
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1150.5
Subject(s) - anastrozole , urology , prostate , medicine , aromatase inhibitor , testosterone (patch) , aromatase , endocrinology , levator ani , orchiectomy , anatomy , pelvic floor , cancer , breast cancer
Our purpose was to determine the role of the aromatase enzyme in mediating the myotrophic and prostate enlarging effects of androgens. 10 month old Fisher 344 rats received Sham surgery or orchiectomy (ORX). One week following surgery animals were implanted with motorized micro‐infusion pumps to disperse anastrozole (ANA; aromatase inhibitor) or vehicle at a rate of 2.0 μl/hour. Animals received once weekly IM testosterone enanthate (TE; 7.0mg/week), trenbolone enanthate (TREN; 1.0mg/week), or vehicle. 28 days following pump implantation animals were sacrificed and the prostate and levator ani‐bulbocavernosus (LABC) muscle were excised.Group (n=3) Prostate (g) LABC (g)SHAM (a) 0.29±0.064 c 0.88±0.033 b,c,d,e,f,g ORX (b) 0.07±0.014 d,e 0.45±0.004 d,e,f,gORX+ANA (c) 0.06±0.003 a,d,e 0.48±0.025 d,e,f,gORX+TE (d) 0.31±0.037 b,c 1.20±0.034 a,b,cORX+TE+ANA (e) 0.31±0.074 b,c 1.22±0.046 a,b,cORX+TREN (f) 0.15±0.064 1.19±0.035 a,b,cORX+TREN+ANA (g) 0.18±0.033 1.19±0.013 a,b,cValues are mean±SEM. Significance values are reported from one‐way ANOVA and Tukey posthoc group comparison; letters indicate p<0.05 vs. group.Our findings suggest that estradiol is not required for androgen mediated prostate enlargement. Further, inhibiting the aromatase enzyme did not blunt the myotrophic effects of androgens. Supported by VA Merit Award to SEB and VA Geriatrics Fellowship to DTB.