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Chronic α 1A AR stimulation may increase adult neurogenesis and parvalbumin interneurons
Author(s) -
Nielsen Amber,
Collette Katie,
Perez Dianne,
Doze Van
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1146.8
Subject(s) - neurogenesis , subventricular zone , parvalbumin , subgranular zone , neuroscience , dentate gyrus , psychology , neural stem cell , biology , hippocampus , stem cell , microbiology and biotechnology
Adult neurogenesis occurs in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus. It seems to play a role in mood, cognition, epilepsy, and schizophrenia with increases having a positive effect. Chronic stimulation of α 1A ‐adrenergic receptors (α 1A ARs) has been shown to increase adult neurogenesis in the SVZ; however, its effects have not yet been thoroughly explored in the SGZ. Persons suffering from schizophrenia have decreased numbers of parvalbumin‐positive (PV + ) interneurons. Preliminary work in our lab has shown an increase in PV + interneurons after chronic activation of the α 1A AR. The present study investigated the impact of chronic α 1A AR stimulation on neurogenesis and on PV + interneuron numbers in the adult SGZ. Constitutively active mutant (CAM) α 1A AR mice, which have chronically activated α 1A ARs, were used and compared with control animals. The results indicate a possible increase in BrdU + cells and PV + interneurons. Treatments to increase adult neurogenesis may be used to treat depression and anxiety in the future. Similarly, treatments to increase adult neurogenesis and PV + interneurons may improve symptoms of schizophrenia. Supported by North Dakota EPSCoR IIP Seed Award Grant EPS‐081442, National Center for Research Resources Grant P20RR016741 and National Institute of General Medical Sciences Grant P20GM103442 from the NIH, NHLBI Grant RO1HL61438, American Physiological Society Undergraduate Summer Research Fellowship, NSF Graduate Research Fellowship Program, and NSF MRI Grant 0619688.