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Increased respiratory rhythm and O2 and CO2 chemosensitivity in juvenile rats submitted to perinatal protein undernutrition
Author(s) -
CostaSilva João Henrique,
Alves José Luiz B.,
Nogueira Viviane O.,
Oliveira Gerliny B.,
Da Silva Glauber S.F.,
Wanderley Almir G.,
Leandro Carol V.G.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1137.17
Subject(s) - hypercapnia , hypoxia (environmental) , endocrinology , medicine , lactation , tidal volume , respiratory system , offspring , chemistry , zoology , biology , oxygen , pregnancy , genetics , organic chemistry
We evaluated the effects of perinatal protein undernutrition on the respiratory pattern and responses to hypercapnia and hypoxia. Pregnant Wistar rats received normoproteic (NP, 17% of protein) or hypoproteic diet (HP, 8% of protein) during gestation and lactation. Male offspring (NP: n=10; HP: n=10) at the 30‐day‐old were evaluated for respiratory frequency (Rf), tidal volume (V T ) and ventilation (VE), and ventilatory responses to hypercapnia (10% CO 2 ) and hypoxia (7% O 2 ). At rest, HP rats showed increased Rf (NP: 105.3±3.1 vs. HP: 135.1±2.2 cycles.min −1 , P<0.0001) and Ve (NP: 987.4±36.1 vs. HP: 1384.9±57.1 mL.kg − 1 .min −1 , P<0.0001), but no change in V T . After exposure to hypercapnia, HP showed higher ventilatory responses than NP rats in Rf (NP: 170.5±2.8 vs. E: 181±3.5 cycles.min −1 , P=0.02) and Ve (C: 2349.1±111.1 vs. E:2769.8±151.8 mL.kg −1 .min −1 , P=0.03). Likewise, hypoxia‐induced ventilatory responses were increased in HP rats in Rf (NP: 116.9 ±4.1 n= 5 vs. HP: 146.1±4.4 resp.min −1 , p=0.0010), V T (NP: 12.0±0.7 vs HP: 16.5 ±1.2 mL.kg −1 , p=0.0135) and Ve (NP: 1449.5 ±114.9 vs. HP: 2454.3 ± 175.0 mL.kg −1 .min −1 , p=0.0013). Our data suggest that juvenile rats submitted to perinatal protein undernutrition had increase in ventilation at rest and in ventilatory responses to hypercania and hypoxia, which could be a potential hidden basis for the development of arterial hypertension in adulthood. Support: FACEPE and CNPq.