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Overall stress response is reduced in U.S. Marines following infantry training
Author(s) -
Kelly Karen,
Jensen Andrew,
Niederberger Brenda,
Congalton Robert,
Jaworski Rebecca
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1132.26
Subject(s) - medicine , endocrinology , infantry , inflammation , zoology , chemistry , biology , political science , law
This study measured changes in stress proteins during basic U.S. Marine infantry training. Blood samples were obtained at day 0, 12, 28 and 40 at rest and post‐hikes at various distances. Results show that TNFá levels were attenuated (TNFá, pre‐5k: 3.8±0.5, post‐5k: 5.5±0.8, P =0.0005; pre‐20k: 4.3±0.9, post‐20k:4.9±0.9, P=0.39 pg/ml); IL‐6 increased from pre‐ to post hike for both the 5k and 20k (P<0.0001); however there were no differences between the 5k and 20k (蜐5k:3.5±0.8; 蜐20k:3.3±0.2, P>;0.05).There was a trend towards a decrease in CRP (P=0.07). Cortisol showed a linear decline from day 0–28 and plateau during the final week (baseline: 75.6 ±5.5, pre‐5k: 57.2±6.7, pre‐15k: 38.2±3.9, pre‐20k:42.0±3.7; P<0.001). These results suggest that despite an increase in hike duration and intensity was an overall reduced stress response indicating that exercise training can mitigate classical inflammatory protein response. The rise in IL‐6 following the 20k, independent of change in TNFá, suggests that IL‐6 is acting to regulate metabolism rather than inflammation. The lack of rise in IL‐6 between the 5k and 20k is indicative of an increased reliance on lipid metabolism rather than glucose, which IL‐6 is known to regulate. In summary, despite the increased physical stress over the course of infantry training, physiological adaptations occur to mitigate inflammation and regulate metabolism.