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Lower potassium intake is associated with increased wave reflection in young healthy males
Author(s) -
LenEdwards Shan,
Schellhardt Taylor,
Allman Brittany,
Farquhar William B,
Edwards David G
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1125.9
Subject(s) - pulse wave velocity , excretion , endocrinology , medicine , blood pressure , potassium , arterial stiffness , sodium , chemistry , diastole , organic chemistry
Increased potassium intake has been shown to lower blood pressure (BP) even in the presence of high sodium consumption however the role of dietary potassium on vascular function has received less attention. The objective of this study was to evaluate the relationship between habitual intake of sodium (Na) and potassium (K) and measures of arterial stiffness and wave reflection. 20 healthy males (24±0.7 yrs; systolic BP 121±3; diastolic BP 64±2 mmHg) recorded their dietary intake for 3 days and collected their 24‐hr urine on the 3rd day. Carotid‐femoral pulse wave velocity (PWV) and the synthesis of a central aortic pressure waveform (by radial artery applanation tonometry and generalized transfer function) were performed. Aortic augmentation index (AI), an index of wave reflection, was calculated from the aortic pressure waveform. Subjects consumed an average of 2,492 kcals, 4,212 mg Na, and 2,967 mg of K. Average urinary Na/K excretion ratio was 2.69±0.3. An inverse relationship between AI and K excretion was found (r= −0.3122; p<0.001) while no relationship was noted with Na excretion (r= − 0.005; p>;0.05). AI positively correlated with the Na/K excretion ratio (r= 0.153; p<0.05). PWV did not correlate with either nutrient or the Na/K excretion ratio (p>;0.05). These data suggest that lower potassium intakes are associated with stiffer arteries in young healthy males. Supported by R01 HL 104106.