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Carotid artery intima‐media echogenicity and aortic stiffness in healthy middle‐aged and older humans
Author(s) -
Aizawa Kunihiko,
Elyas Salim,
Adingupu Damilola D,
Casanova Francesco,
Gooding Kim M,
Mawson Dave M,
Shore Angela C,
Strain W David,
Gates Phillip E
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1125.8
Subject(s) - arterial stiffness , echogenicity , pulse wave velocity , medicine , cardiology , common carotid artery , aorta , intima media thickness , body mass index , carotid arteries , ultrasound , blood pressure , radiology
Echogenic carotid plaque has been shown to be related to aortic stiffness. However, whether a similar relationship is observed between carotid artery intima‐media complex echogenicity (IM‐GSM) and aortic stiffness is not known. This study examined the relationship between IM‐GSM and aortic stiffness in 94 healthy middle‐aged and older individuals (62.9±8.2 yrs, 50F). B‐mode ultrasound images of the common carotid arteries were analyzed by semi‐automated software for IM‐GSM and intima‐media thickness (IMT), and aortic stiffness was assessed by carotidfemoral pulse wave velocity (cfPWV) using applanation tonometry. In univariate analysis, age (r=−0.22), body mass index (r=−0.31), IMT (r=−0.56), mean arterial pressure (r=−0.35), fasting glucose (r=−0.31), and cfPWV (r=−0.41) were all inversely associated with IM‐GSM (all p<0.05). In multivariate analysis, cfPWV was an independent determinant of IM‐GSM together with IMT, body mass index and fasting glucose (total R 2 =0.381). These results demonstrate that IM‐GSM is inversely associated with aortic stiffness, suggesting an interaction between arterial stiffness and the composition of the carotid artery intima‐media complex with ageing.