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Identifying markers of insulin resistance in the plasma proteome
Author(s) -
Jamnik Joseph,
GarciaBailo Bibiana,
Borchers Christoph,
ElSohemy Ahmed
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.112.6
Subject(s) - insulin resistance , adiponectin , vitronectin , medicine , population , endocrinology , serum amyloid a , blood proteins , haptoglobin , type 2 diabetes , hemopexin , biology , diabetes mellitus , insulin , inflammation , receptor , biochemistry , integrin , heme , enzyme , environmental health
Type 2 diabetes (T2D) represents a significant global health problem. The plasma proteome comprises numerous high‐abundance proteins that may be associated with the development of T2D. The objective was to determine the association between HOMA‐IR, a common measure of insulin resistance, and 54 plasma proteins belonging to disease‐associated pathways in a population of healthy young adults (n=488) from the Toronto Nutrigenomics and Health Study. Protein concentrations were measured by a multiple reaction monitoring HPLC‐MS/MS assay. General linear models were used to assess the association between plasma proteins and HOMA‐IR. Analyses were adjusted for age, sex, ethnicity, waist circumference, physical activity, and contraceptive use among women. Hemopexin, complement factor H, heparin cofactor II, afamin, α 1 ‐anti‐trypsin, α 2 ‐HS‐glycoprotein, apolipoprotein L1, complement C3, serum amyloid P‐component, vitronectin, and transthyretin were significantly ( p <0.0009) positively correlated with HOMA‐IR. Adiponectin, an anti‐inflammatory protein, was inversely correlated with HOMA‐IR. These results suggest that a number of plasma proteins may be useful biomarkers of insulin resistance and T2D risk. Research support from the Advanced Foods and Materials Network.