Premium
Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations
Author(s) -
Kroeger Cynthia M.,
Klempel Monica C.,
Bhutani Surabhi,
Trepanowski John F.,
Varady Krista A.
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.112.1
Subject(s) - adipokine , medicine , intermittent fasting , endocrinology , waist , leptin , regimen , calorie restriction , lipid profile , obesity , cholesterol
Background The ability of an intermittent fasting (IF)‐calorie restriction (CR) regimen (with or without liquid meals) to modulate adipokines in a way that is protective against coronary heart disease (CHD) has yet to be tested. Objective Accordingly, we examined the effects of an IFCR diet on adipokine profile, body composition, and markers of CHD risk in obese women. Methods Subjects (n = 54) were randomized to either the IFCR‐liquid (IFCR‐L) or IFCR‐food based (IFCR‐F) diet for 10 weeks. Results Greater decreases in body weight and waist circumference were noted in the IFCR‐L group (4 ± 1 kg; 6 ± 1 cm) versus the IFCR‐F group (3 ± 1 kg; 4 ± 1 cm). Similar reductions (P < 0.0001) in fat mass were demonstrated in the IFCR‐L (3 ± 1 kg) and IFCR‐F group (2 ± 1 kg). Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR‐L (19 ± 10%; 20 ± 9%, respectively) versus the IFCR‐F group (8 ± 3%; 7 ± 4%, respectively). LDL peak particle size increased (P < 0.01) in the IFCR‐L group only. The proportion of small LDL particles decreased (P < 0.01) in both groups. Adipokines, such as leptin, interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐alpha), and insulin‐like growth factor‐1 (IGF‐1) decreased (P < 0.05), in the IFCR‐L group only. Conclusion These findings suggest that IFCR with a liquid diet favorably modulates visceral fat and adipokines in a way that may confer protection against CHD.