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Afferent Vagal Nerve Stimulation Resets the Baroreflex Neural Arc and Inhibits Sympathetic Nerve Activity
Author(s) -
Saku Keita,
Sakamoto Kazuo,
Hosokawa Kazuya,
Kakino Takamori,
Ikeda Masataka,
Oga Yasuhiro,
Nishizaki Akiko,
Ide Tomomi,
Sunagawa Kenji
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1118.10
Subject(s) - baroreflex , stimulation , afferent , arc (geometry) , baroreceptor , anesthesia , chemistry , medicine , endocrinology , blood pressure , heart rate , geometry , mathematics
Background Vagal nerve stimulation (VNS) benefits patients with heart failure. The afferent vagal nerve mediates cardiopulmonary reflex. We hypothesized that vagal afferent stimulation (AVNS) suppresses sympathetic nerve activity (SNA) and improves heart failure. Methods and Results In 5 ventilated rats, we controlled the isolated, bilateral carotid sinuses pressure (CSP) and measured celiac SNA and AP. In the presence of constant CSP, increasing the voltage of AVNS captured the vagal afferent nerves at 2.7±0.7 volts and dose dependently decreased SNA and AP with a maximal inhibition of SNA at 5.5±1.2 volts. We changed CSP stepwise and measured SNA and AP. AVNS shifted the CSP‐SNA relation (neural arc) downward, whereas unaffected the SNA‐AP relation (peripheral arc). To evaluate the dynamic impacts of AVNS, we randomly stimulated AVNS with binary white noise sequence, and identified the transfer functions from AVNS to SNA (H AVNS‐SNA ) and from the SNA to AP (H SNA‐AP ). H AVNS‐SNA resembles that of the neural arc, while H SNA‐AP resembles that of the peripheral arc indicating AVNS induces sympathoinhibition just like baroreflex. Conclusion AVNS resets the baroreflex neural arc and induces sympathoinhibition. It may in part attribute to the beneficial impacts of VNS on heart failure.