Premium
Weight‐loss surgery rapidly alleviates platelet hyperactivity in morbid obesity
Author(s) -
Dobrydneva Yuliya,
Periasamy Monica,
Butcher Matthew,
Galkina Elena,
Kuhn Norine,
Lieb David,
Fontana Mark,
Wohlgemuth Steven,
Nadler Jerry
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1114.1
Subject(s) - medicine , platelet , diabetes mellitus , platelet activation , morbid obesity , gastric bypass surgery , thrombosis , weight loss , gastroenterology , obesity , morbidly obese , gastric bypass , surgery , anesthesia , cardiology , endocrinology
Morbid obesity is accompanied by platelet hyperactivity, leading to thrombotic events such as myocardial infarction and stroke. Platelets are pivotal for development of thrombosis. Bariatric surgery is the most effective intervention to reduce thrombotic events and alleviate type II diabetes in morbidly obese. However, effect of bariatric surgery on platelet function is largely unknown. In this pilot study we compared the short‐term effects of Roux‐en‐ Y Gastric Bypass (RY) and Lap Banding (LB) on prothrombotic monocyte‐platelet aggregates (MPA) that reflect platelet activation in vivo. MPA were measured in whole blood by flow cytometry pre‐ and post‐surgically at 1 and 3 months. In morbidly obese patients, MPA are drastically elevated compared to non‐obese controls. Both RY and LB decreased MPA in blood (unstimulated and stimulated with ADP). However RY alleviated platelet hyperactivity more rapidly (at 1 month post‐op) and more profoundly compared to LB. Bariatric surgery decreased MPA more profoundly in diabetics than in non‐diabetics. There is no correlation between BMI and decreased platelet activation after RY, but there is strong correlation after LB. Decreased MPA also correlates with decreased IL‐6 post‐surgically. Thus gastric bypass is more efficacious than gastric banding to reduce platelet hyperactivity in morbid obesity leading to a reduction in thrombotic events.