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Estrogen supplementation increases renal sodium absorption during high salt consumption in female and male mice
Author(s) -
Rouch Al,
Kudo Lucia,
Nguyen Sarah,
Nadeem Maria
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1112.2
Subject(s) - ovariectomized rat , estrogen , medicine , endocrinology , pellet , excretion , placebo , chemistry , zoology , biology , alternative medicine , pathology
The purpose of this study was to determine the effects of estrogen supplementation on the renal excretion of Na + (U Na · V) in CD‐1 mice. Two studies were conducted – one with females and one with males. Female groups (n=4/group) included normal (NF), ovariectomized implanted with a placebo pellet (OP), and ovariectomized with a 0.1 mg estrogen pellet (OE). Male groups included normal (NM), castrated with placebo pellet (CP), and castrated with estrogen pellet (CE). Pellets were purchased from Innovative Research of America (Sarasota, FL). Mice in metabolic cages consumed 1% salt diet for 5 days, 4% salt for the next 15 days, and 1% salt for the final 5 days. No differences occurred during the 1% salt periods. Average U Na · V (μEq/day ± se) for the 4% salt periods were: females: 1652±92, 2011±82*, 1457±106† (NF, OP, OE, respectively); and males: 1976±163, 2154±153, 1312±100*† (NM, CP, CE, respectively) (*p<.01 compared to NF or NM; † ‐ p<0.01 compared to OP or CP). We conclude that estrogen administration yields significant renal Na + absorption during high salt loads in female and male mice. Results suggest a sex difference in Na + excretion during high salt consumption.