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Computer modeling of peristaltic contraction and solute concentration in 3D inner medulla of the rat
Author(s) -
Lee Pilhwa,
Beard Daniel
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1111.9
Subject(s) - chemistry , biophysics , renal medulla , medulla , contraction (grammar) , renal papilla , mechanics , anatomy , kidney , physics , endocrinology , biology
The primary physiological mechanism governing concentration of solutes in the renal inner medulla is thought to be the passive permeation of the solutes through tubules. Yet it is recognized that other factors, such as contraction of the renal papilla, contribute to the concentration mechanism. In order to investigate how tubular water transport is affected by pelvic contraction, we developed a computational model based on a realistic three‐dimensional representation of the inner medulla. The advection and diffusion of solutes in the intra‐tubular domains are described in a Lagrangian formulation. The diffusion of solutes at the extra‐tubular domain and the interstitial fluid flow is described in the Eulerian domain. The osmotic effect across the tubule is represented by the radial change of the tubule governed by Darcy's law. Model simulations reveal the potential effects of contraction on concentration gradients in the papilla.