Premium
Electroacupuncture and Moxibustion Hinder the Progression of Renal Disease by Modulating Systemic and Renal Renin‐Angiotensin System (RAS)
Author(s) -
Naves Marcelo Andery,
Paterno Josne Carla,
Jara Zaira palomino,
Fernandes Fernanda Barrinha,
Casarini Dulce Elena,
Sales Elizabeth Oliveira,
Paulo Castro Teixeira Vicente
Publication year - 2013
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.27.1_supplement.1110.25
Subject(s) - medicine , nephrectomy , moxibustion , renin–angiotensin system , electroacupuncture , angiotensin ii , proteinuria , endocrinology , vasodilation , plasma renin activity , kidney , urology , acupuncture , receptor , blood pressure , pathology , alternative medicine
AND AIMS Systemic and renal RAS are pivotal for the development and maintenance of renal disease. Traditional Chinese Medicine (TCM) is increasingly recognized as an effective therapy in several fields of medicine. Among its therapeutic strategies are eletroacupuncture (EA) and moxibustion (MO). We investigate the effects of EA and MO on RAS in an experimental model of hypertensive and progressive renal disease. METHODS Male wistar rats were submitted to 5/6 nephrectomy (5/6 nx) and studied along eight weeks. There were threee groups: 5/6 nx (NX), 5/6 nx and sham EA (NX‐AS); 5/6 nx and EA‐MO session real acupuncture points (NX‐AM). We evaluated 24h‐proteinuria, plasma and renal Ang I, Ang II and Ang 1–7 and plasma renin activity. RESULTSGroups Ang I (ng/mL) Ang II (ng/mL) Ang 1–7 (ng/mL) Renin ActivityNX 50 ± 13.5 ψ 58.7 ± 19.9 ψ 4 ± 2.1 22.9 ± 7.2 NX‐AS 25 ± 6.6 22.5 ± 6.2 5 ± 1.3 40.1 ± 0.9 NX‐AM 88 ±21.6 # 32 ± 9.1 # 15.8 ± 7.2 * 29.8 ± 4.6 ** (p=<0,05) vs NX and NX‐AS;# (p=<0,05) vs NXAS;ψ (p=<0,05) vs NX‐AS and NX‐AMCONCLUSIONS EA‐MO modulated RAS leading to higher production of systemic and renal Ang 1–7 . Since A 1–7 is protective against endothelial dysfunction and has vasodilatory and antifibrotic effects, our findings suggest that it could be contribute to the improvement of the progression of renal disease in this model.